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营养状况和炎症标志物作为儿科中枢神经系统瘤的生存预测因素
Isabelle Cristine Lôpo Dos Santos1, Gabrielle da Silva Vargas Silva1, Leonardo Borges Murad1
1Nutrition and Dietetics Section, Brazilian National Cancer Institute Jose Alencar Gomes da Silva (INCA), Rio de Janeiro, RJ, Brazil.
Clinical nutrition ESPEN
|September 22, 2023
概括
治疗前高的中性粒细胞与淋巴细胞比率 (NLR) 预测中枢神经系统 (CNS) 瘤的儿科患者的整体存活率较差. 营养状况不是一个重要的预后因素.
科学领域:
- 儿科瘤学 儿科瘤学
- 癌症生物标志物 癌症生物标志物
- 临床研究 临床研究
背景情况:
- 中枢神经系统 (CNS) 瘤是第二常见的儿童恶性瘤.
- 炎症和营养状况被认为是儿科中枢神经系统瘤的潜在预后标志物.
研究的目的:
- 评估营养状况和炎症标志物对儿童中枢神经系统瘤患者整体生存期 (OS) 的预测价值.
主要方法:
- 在5年内对103名中枢神经系统瘤儿科患者进行了回顾性队列研究.
- 收集的临床,人体测量和血液学数据;计算的BMI/A,NLR和SIRI.
- 使用Kaplan-Meier,Log-Rank测试和Cox比例危险模型来分析预后因素.
主要成果:
- 营养状况没有显著影响OS.
- 较高的NLR (≥2.18) 和SIRI (≥1249.18) 与明显较低的5年生存率相关.
- 治疗方式和高NLR是恶化OS的独立预后因素.
结论:
- 治疗前的中性粒细胞与淋巴细胞比率 (NLR) 是儿童中枢神经系统瘤整体存活时间的独立预后因素.
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