在美国人口中,饮食,循环烯酸盐度和心脏代谢健康之间的相互作用
1Department of Nutrition, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA.
Gut
|September 22, 2023
概括
肠道微生物和食纤维可以预测英多 propionate (IPA) 的含量. 较高的IPA与较低的2型糖尿病风险有关,而其他托代谢物增加了风险.
科学领域:
- 微生物组研究的研究.
- 代谢学 代谢学 代谢学
- 营养科学 营养科学
背景情况:
- 印度烯酸 (IPA) 是一种肠道微生物代谢物,具有潜在的健康影响.
- 饮食和肠道微生物群组成影响循环IPA度.
- 了解IPA在2型糖尿病 (T2D) 和冠心病 (CHD) 等代谢性疾病中的作用至关重要.
研究的目的:
- 确定与IPA生产相关的肠道微生物物种.
- 调查影响IPA水平的饮食微生物群相互作用.
- 检查IPA与T2D和CHD风险的潜在关联.
主要方法:
- 对男性参与者的便和血液样本进行分析.
- 使用7天记录评估饮食摄入量.
- 一项前性队列研究,包括来自多项大型研究 (NHS,NHSII,HPFS) 的13,000多名参与者.
主要成果:
- 17种微生物物种与血IPA度显著相关.
- 较高的IPA度与较高的托摄入量有关,但仅在高纤维摄入量和特定微生物特征的人群中.
- 血IPA升高与T2D风险降低有关 (HR 0.70),而其他托代谢物显示T2D风险增加.
结论:
- 肠道微生物群和食纤维协同影响循环IPA水平.
- IPA对2型糖尿病风险具有保护作用,与其他托代谢物形成鲜明对比.
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