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Updated: Jun 17, 2026

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基于驼纳米体的B7-H3 CAR-T细胞显示出对大型固体瘤的高疗效

Dan Li1, Ruixue Wang1, Tianyuzhou Liang1

  • 1Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, 20892, USA.

Nature communications
|September 22, 2023
PubMed
概括

针对B7-H3的IgC表位体与基于纳米体的化学抗原受体T (CAR-T) 细胞,在小鼠中显示出强大的抗瘤活性. 这种方法增强了用于固体瘤免疫治疗的CAR-T细胞功能.

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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
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Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.