药物诱导的社会联系:MDMA和甲基胺在受控的双向对话中增加了连接感
Hanna Molla1, Royce Lee1, Sonja Lyubomirsky2
1Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.
Scientific reports
|September 22, 2023
概括
在对话中,MDMA和甲基胺显著增加了连接感. 虽然这两种药物都会提高催产素水平,但只有MDMA显示了催产素与与伴侣更亲密的感觉之间的相关性.
科学领域:
- 心理药理学 心理药理学
- 社会神经科学是一种社会神经科学.
- 行为科学 行为科学
背景情况:
- MDMA (3,4-methylenedioxymethamphetamine) 以其同情和亲社会效应而闻名.
- 它作为心理治疗的辅助剂的潜在治疗价值得到了认可,但影响社会互动的确切行为机制仍然不清楚.
- 了解MDMA如何影响社会联系对于娱乐用途和临床应用都至关重要.
研究的目的:
- 为了研究MDMA对随便对话中的连接感的影响.
- 通过将MDMA与甲基胺 (MA) 进行比较,确定这些效应的药理特异性.
- 探索催产素在调解这些亲社会效应中的作用.
主要方法:
- 进行了两项研究:一项检查MDMA (100mg与安慰剂对比,N=18) 和另一项检查MA (20mg与安慰剂对比,N=19).
- 参与者与一个不熟悉的伴侣进行半结构化的随意对话.
- 在这两项研究中测量了催产素水平,以评估荷尔蒙变化.
主要成果:
- 与安慰剂相比,MDMA和MA都显著增加了与对话伙伴的联系感.
- 这两种药物也导致了催产素水平的增加.
- 特别是在MDMA给药后,观察到催产素水平和亲密感的增加之间的相关性.
结论:
- MDMA在社交互动中增强了连接感,代表了显著的亲社会效应.
- 令人惊的是,甲基胺在联系上表现出类似的影响,这表明共享的途径或更广泛的兴奋剂诱导的社交.
- 这些发现突出了MDMA社会影响的新维度,并引入了一种敏感的方法来评估二次接触中的亲社会效应.
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