苏尔巴克坦/杜罗巴克坦与特定静脉注射药物的物理兼容性,在模拟Y位处方过程中
Victor H Ruiz1, Yuwei Shen1, Yasmeen Abouelhassan1
1Center for Anti-infective Research and Development, Hartford Hospital, Hartford, CT, USA.
概括
苏尔巴克坦/杜尔洛巴克坦在Y位处方期间与大多数静脉注射药物兼容. 这项研究评估了与95种静脉注射药物的兼容性,发现与其中86种药物同时使用是安全的.
科学领域:
- 药理学 药理学是指药理学的学科.
- 传染性疾病 传染性疾病
- 临床药房 临床药房
背景情况:
- 宝曼尼菌 (Acinetobacter baumannii),特别是耐卡巴胺和多药耐药菌株,在医疗保健环境中构成重大威胁.
- 苏尔巴克坦/杜尔洛巴克坦是一种新型抗生素组合,旨在对抗这些具有挑战性的感染.
研究的目的:
- 为了评估sulbactam/durlobactam在通过Y位与广泛的静脉注射 (IV) 药物同时使用时的物理兼容性.
- 在临床实践中提供安全药物管理的基本数据.
主要方法:
- 硫巴克坦/杜尔洛巴克坦溶液在模拟的Y位条件下以1:1的比例与95种不同的静脉注射药物溶液准备并混合.
- 物理特征,包括清晰度,颜色,Tyndall效应,度和pH值,在混合后的4小时内进行了监测.
主要成果:
- 苏尔巴克坦/杜尔洛巴克坦与95种试验的药物中的86种 (90.5%) 具有物理兼容性.
- 特别的不相容性被注意到与阿尔伯,阿米奥达龙化,塞夫塔罗林福萨米尔,西普罗夫洛克萨,达普托米,莱沃弗洛克萨,胺,维库和普罗波.
结论:
- 这项研究提供了关键的Y部位兼容性数据,用于硫巴克坦/杜罗巴克坦与众多静脉注射药物.
- 这些发现将有助于医疗保健专业人员,包括药剂师和护士,安全地与其他静脉注射疗法同时使用硫巴克坦/杜罗巴克坦.
相关概念视频
01:25Routes of Drug Administration: Parenteral
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The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
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01:19One-Compartment Open Model for IV Bolus Administration: General Considerations
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The one-compartment model is a pharmacokinetic tool that models the body as a single, uniform compartment, facilitating the understanding of drug distribution and elimination. This model is particularly beneficial for intravenous (IV) bolus administration, where the drug rapidly circulates throughout the body.
The drug's presence in the body is defined by an equation representing the difference between the rates of drug entry and exit. Key parameters—elimination rate constant,...
The drug's presence in the body is defined by an equation representing the difference between the rates of drug entry and exit. Key parameters—elimination rate constant,...
232
01:18Two-Compartment Open Model: IV Bolus Administration
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The two-compartment model for intravenous (IV) bolus administration illustrates drug distribution in the body, subdividing it into central and peripheral compartments. This model operates on the concept of two-compartment kinetics. The drug's plasma concentration shows a bi-exponential decline following IV bolus administration, signaling the presence of two disposition processes: distribution and elimination.
The disparity between drug input and the sum of drug transfer rates between...
The disparity between drug input and the sum of drug transfer rates between...
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01:29Drug Delivery: Parenteral Route
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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
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01:11Nondepolarizing (Competitive) Neuromuscular Blockers: Pharmacokinetics
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All neuromuscular blocking agents are injected intravenously because they are poorly absorbed from the GI tract. Rapid onset is achieved with intravenous administration, although absorption is also adequate from an intramuscular injection. Since these agents are highly ionized, they do not readily penetrate cell membranes or cross the blood-brain barrier.
Instead, they are transported by the blood to different tissues. Muscles with a greater blood supply (arteries) and blood flow receive more...
Instead, they are transported by the blood to different tissues. Muscles with a greater blood supply (arteries) and blood flow receive more...
469
01:30Drug Binding to Blood Components
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When drugs enter systemic circulation, they interact with various components of the blood, including proteins such as human serum albumin (HSA), α1-acid glycoprotein (AAG), lipoproteins, globulins, and red blood cells (RBCs).
HSA is the most abundant plasma protein and is vital in drug binding. It contains distinct drug-binding sites, with different drugs exhibiting affinity for specific sites. There are three main drug-binding domains for HSA: sites I, II, and III. These domains are...
HSA is the most abundant plasma protein and is vital in drug binding. It contains distinct drug-binding sites, with different drugs exhibiting affinity for specific sites. There are three main drug-binding domains for HSA: sites I, II, and III. These domains are...
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