相关实验视频

Updated: Jul 16, 2025

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Published on: January 29, 2019

对于增强瘤放射免疫治疗的离子恒温的调节

Rui Qian¹, Xuan Yi², Teng Liu³

¹Department of General Surgery and Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University, Guangzhou, 510000, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|September 23, 2023

概括

这项研究引入了生物相容纳米粒子 (CCL),通过调节细胞内/细胞外离子含量来增强瘤放射免疫疗法. CCL使瘤的pH和水平正常化,提高了放射治疗的疗效和对瘤的免疫反应.

科学领域:

生物医学工程生物医学工程
纳米医学是一种纳米医学.
癌症治疗癌症治疗

背景情况:

瘤的离子含量显著影响癌症的生长,转移和治疗结果.
调节瘤微环境对于增强抗瘤疗法至关重要.

研究的目的:

开发生物相容纳米粒子 (CaCO3/CAI@Lipsome - CCL) 用于改善瘤放射性免疫治疗.
研究CCL对细胞内/细胞外离子含量的影响及其在增强治疗疗效方面的作用.

主要方法:

在对pH反应的碳酸 (CaCO3) 纳米颗粒上加载碳酸碳酶抑制剂 (CAI).
用脂质体对纳米粒子进行修改,以创建生物相容的CCL.
评估瘤微环境中的CCL分解,离子释放和pH调节.
评估CCL对瘤细胞对放射治疗的敏感性,过载,免疫细胞死亡和巨细胞极化的影响.

主要成果:

CCL在瘤微环境中分解,释放Ca2+和CAI,并增加细胞外pH值.
CAI使瘤酸度正常化,增强放射治疗的敏感性,促进细胞内H+积累.
放射治疗与CCL结合,诱导细胞过载,增强免疫细胞死亡和树突细胞成熟.
CCL治疗将M2瘤相关的巨细胞分化为抗瘤M1表型.

结论:

CCL有效调节细胞内/细胞外瘤细胞的pH和水平.
这种多方向的离子调节显著提高了放射性免疫治疗的疗效.
开发的纳米制剂为改善癌症治疗结果提供了一个强大的策略.

关键词:

过载的离子过载免疫性细胞死亡免疫性细胞死亡放射性免疫疗法是一种放射性免疫疗法.瘤酸性中和化瘤酸性中和化

更多相关视频

Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics

Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics

Published on: December 1, 2023

Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches

Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches

Published on: June 16, 2023

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...