皮洛替尼加抗血管原剂治疗HER2改变的高级非小细胞肺癌:一项回顾性现实研究
Yaning Yang1, Guangjian Yang2, Weihua Li3
1Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
与抗血管原剂相结合的皮罗替尼在患有 HER2 变异非小细胞肺癌 (NSCLC) 的患者中显示出有希望的有效性和耐受性. 这种组合疗法为晚期NSCLC提供了可行的治疗选择,当其他疗法有限时.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 针对HER2变异非小细胞肺癌 (NSCLC) 的向疗法显示出有效性,但在成本和可用性方面面临挑战.
- 需要为患有先进的HER2-改变NSCLC的患者提供可访问和有效的治疗选择.
研究的目的:
- 评估pyrotinib加抗血管原剂 (apatinib,anlotinib,bevacizumab) 的疗效和安全性,用于先前治疗HER2改变的晚期NSCLC的患者.
- 在患者队列中评估这种组合治疗的现实结果.
主要方法:
- 对107名 HER2 变异性NSCLC 患者的回顾性分析,这些患者接受了 pyrotinib 加上抗血管原剂的治疗.
- 对客观反应率 (ORR),疾病控制率 (DCR),无进展生存率 (PFS),总生存率 (OS) 和安全概况的评估.
- 患者在2015年11月至2022年1月期间接受了二线或后一线治疗.
主要成果:
- 客观应答率 (ORR) 为19.6%,疾病控制率 (DCR) 为94.4%.
- 无进展生存时间 (PFS) 中位数为7.13个月,总生存时间 (OS) 中位数为19.50个月.
- 最常见的3级或更高的不良事件是腹 (17.6%) 和高血压 (11.0%);没有发生与治疗相关的死亡.
结论:
- 皮洛替尼加抗血管原剂在HER2改变的NSCLC患者中显示出有前途的疗效.
- 这种组合疗法耐受性很好,对于以前接受过治疗的患者来说,它是一个可行的治疗选择.
- 这些发现支持在管理先进的HER2-改变NSCLC时使用pyrotinib和抗血管原剂.
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