来自Micromonospora sp. 的J和K的微安萨米. 香港160111mas13OEOE 的价格
Jianxiong Wang1, Chunhua Lu1, Yajie Tang2
1Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China.
Natural product research
|September 23, 2023
概括
从Micromonospora发现了两个新的微安萨米辛,J和K. 这些新型的pentaketide安萨米辛对常见的细菌菌株没有表现出抗菌活性.
科学领域:
- 自然产品化学 自然产品化学
- 微生物学 微生物学
- 有机化学 有机化学
背景情况:
- 微安萨米辛是一种新型五基胺安萨米辛的一类.
- 这些化合物是从Micromonospora物种中分离出来的,并且具有独特的AHBA-C2-C2-C3-C3骨架,具有PKS后的修饰.
研究的目的:
- 来自Micromonospora sp.的新型微安萨米辛的鉴定和特征. 香港160111mas13OE. 的时间.
- 评估新发现的化合物的抗菌潜力.
主要方法:
- 从Micromonospora中分离和净化微安萨米辛.
- 使用核磁共振 (NMR) 和高分辨率电喷射电离化质谱法 (HRESIMS) 阐明结构.
- 对黄金葡萄球菌和大肠杆菌的抗菌活性测试.
主要成果:
- 发现了两种新的微安萨米辛,被指定为J (1) 和K (2).
- 这些结构通过光谱数据和与已知的同源 (microansamycins F和E) 的比较来证实.
- 无论是microansamycins J还是K都没有在40μg/mL时对测试的菌株表现出显著的抗菌活性.
结论:
- 这项研究扩大了已知的微安萨米辛的化学多样性.
- 新发现的微安萨米辛J和K缺乏对黄金葡萄球菌和大肠杆菌的抗菌特性,这表明在这个方面治疗潜力有限.
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