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Updated: Jul 16, 2025

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通过高斯加速分子动力学和主要成分分析来探索由突变介导的Janus kinase 2伪激酶的构造变化

Huayin Bao1, Weikai He2, Jianzhong Chen2

  • 1School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China.

Journal of biomolecular structure & dynamics
|September 23, 2023
PubMed
概括

简氏激酶2 (JAK2) 伪激酶域中的突变改变了它的结构和ATP相互作用. 这影响了JAK2活动监管,为药物设计提供了洞察力.

关键词:
在GaMD模拟中使用了GaMD模拟器.蛋白质氨酸激酶酶是一种蛋白质激酶酶.自由能源的景观.主要组件分析的主要组件分析伪激酶域名 伪激酶域名

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