2型糖尿病患者的步行节奏和微血管并发症:英国生物银行的队列研究
Xinyu Zhu1,2, Xinyu Zhang1,2, Chuandi Zhou1,2
1Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Scandinavian journal of medicine & science in sports
|September 23, 2023
概括
缓慢的步行节奏显著增加了2型糖尿病 (T2D) 患者糖尿病微血管并发症的风险. 这一发现强调了监测步行速度的重要性,作为疾病进展的潜在指标.
科学领域:
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 步行速度是已知的健康结果的指标.
- 糖尿病微血管并发症对2型糖尿病 (T2D) 患者构成重大威胁.
研究的目的:
- 调查自我报告的步行节奏与糖尿病微血管并发症发生率之间的关联.
- 为了确定步行速度是否可以预测T2D患者发展视网膜病变,神经病变或病变的风险.
主要方法:
- 利用了来自英国生物库的14518名患有T2D的参与者的数据.
- 自我报告的步行速度被分类为快速,平均或缓慢.
- 采用COX比例危险模型来分析微血管并发症的风险,调整各种混因素.
主要成果:
- 慢步行者与快步行者相比,患复合微血管并发症 (HR 1.98),糖尿病视网膜病变 (HR 1.54),糖尿病神经病变 (HR 3.26) 和糖尿病病变 (HR 2.32) 的风险明显更高.
- 平均步行速度也与糖尿病脏病的风险增加有关 (HR 1.51).
- 与平均 (19.5%) 和快步 (14.7%) 相比,慢步行者 (30.4%) 的至少一个微血管并发症的发生率明显高.
结论:
- 自我报告的慢步是T2D患者糖尿病微血管并发症的重要独立风险因素.
- 步行速度可以作为一个简单的,可访问的标志物来评估并发症风险和监测T2D的疾病进展.
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