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不相干的光学波动流量计用于检测血液动力学上显著的狭窄的肢体在2型糖尿病患者

Polina Glazkova¹, Alexey Glazkov², Dmitry Kulikov^3,4

¹Moscow Regional Research and Clinical Institute ("MONIKI"), Moscow, Russia. polinikul@mail.ru.

|September 23, 2023

概括

一种新的不连贯的光学波动流量计 (IOFF) 方法显示在糖尿病患者中检测下肢外周动脉疾病 (LE-PAD) 的高精度. 这种快速,易于使用的技术为PAD诊断中的临床应用提供了显著的潜力.

科学领域:

血管医学血管医学
医学诊断医学诊断医学诊断
光学物理学光学物理学

背景情况:

糖尿病患者患下肢外周动脉疾病 (LE-PAD) 的风险很高.
准确,可访问的诊断方法对于LE-PAD在糖尿病 (DM) 中至关重要.
目前的方法,如脚-手臂指数 (ABI) 和穿皮氧度 (TcPO2) 有局限性.

研究的目的:

评估一种新的不连贯光学波动流量计 (IOFF) 方法的诊断准确性.
为了将IOFF的性能与已建立的方法 (ABI,TcPO2) 进行比较,以检测糖尿病患者的严重腿部狭窄症.
评估IOFF在LE-PAD检测中的临床实用性.

主要方法:

一项涉及患有和没有LE-PAD的糖尿病患者的研究.
测量包括超声波 (参考),ABI,TcPO2和新的IOFF方法.
对每个诊断技术的灵敏度,特异性和AUC进行比较分析.

主要成果:

在检测血液动力学显著狭窄症 (AUC 0.890) 方面,IOFF表现出高灵敏度 (79.5%) 和特异性 (89.8%).
TcPO2显示了69.2%的灵敏度和86.2%的特异性 (AUC为0.817).
标准ABI (<0.9) 的灵敏度低 (34.5%),而调整的切线 (0.99) 提高了灵敏度 (84.6%),但降低了特异性 (78%).

结论:

不相干的光学波动流量计 (IOFF) 技术对于在糖尿病患者中检测LE-PAD具有高度敏感性和特异性.
IOFF的准确性,速度和潜在的可用性表明它是临床PAD诊断的一个有希望的工具.
这种方法可以显著帮助在糖尿病人群中早期发现和管理PAD.

关键词:

脚的手臂指数指数不相干的光学波动流量计.周围动脉疾病是什么?通过皮肤进行氧计.

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