肥胖:一个性别观点
G Muscogiuri1,2,3, L Verde4,5, C Vetrani4,6
1Dipartimento Di Medicina Clinica E Chirurgia, Diabetologia E Andrologia, Unità Di Endocrinologia, Università Degli Studi Di Napoli Federico II, Via Sergio Pansini 5, 80131, Naples, Italy. giovanna.muscogiuri@gmail.com.
Journal of endocrinological investigation
|September 23, 2023
概括
性别显著影响肥胖,影响身体脂肪的分布和治疗反应. 了解这些差异对于有效的肥胖管理和药物开发至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 肥胖的流行率和特征表现出性别特异性的模式.
- 了解性别差异对于有效的肥胖管理至关重要.
研究的目的:
- 从性别角度审查关于肥胖的人类,营养和药理方面的现有证据.
- 突出性别在肥胖研究和治疗中的重要性.
主要方法:
- 在PubMed.com内进行的文献搜索.
- 审查了关于肥胖和性别差异的精选出版物.
主要成果:
- 女性的身体脂肪百分比更高,肥胖现象类型不同 (妇科和安卓).
- 在抗肥胖药物试验中,性别特异性分析是不常见的,尽管存在潜在的药理动力学/药理动力学差异.
- 腹部外科手术显示出性别差异的结果和心理挑战.
结论:
- 性别是肥胖患病率,表型和身体脂肪分布的一个关键变量.
- 药物疗效,临床试验代表性和减肥手术结果存在基于性别的差异.
- 需要进一步的研究来解决针对肥胖治疗的性别特异性反应.
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