线粒体DNA单基组D和大脑微观结构调节社区生活中老年人的认知功能
Chuan-Wei Yang1, Chia-Ing Li2, Chiu-Shong Liu3
1Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.
Archives of gerontology and geriatrics
|September 23, 2023
概括
线粒体DNA (mtDNA) 单基组D与老年人较低的认知功能有关. 大脑白质的完整性也影响认知表现,这表明mtDNA和大脑结构在认知衰老中的作用.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 老年学是指老年学的学科.
背景情况:
- 线粒体功能对于维持老年人的身体和认知健康至关重要.
- 线粒体DNA (mtDNA) 单基组可能会影响大脑健康和认知功能.
- 了解这些关系是解决老年人群认知衰退的关键.
研究的目的:
- 调查mtDNA哈普洛组对社区老年人的认知和身体功能的影响.
- 探索与mtDNA单基组有关的大脑微观结构和认知功能之间的关联.
- 确定影响老年人认知表现的因素.
主要方法:
- 对128名65岁以上没有痴呆症的社区成年人进行横截面研究.
- 使用迷你精神状态检查 (MMSE) 和AD8问卷进行认知功能评估.
- 使用mtDNA测序,3TMRI用于大脑微观结构分析,HaploGrep 2用于分类.
主要成果:
- 在对共变量进行调整后,mtDNA哈普洛组D携带者表现出明显较低的MMSE得分 (p=0.047).
- mtDNA哈普洛组D (p=0.002) 和左前白质体积 (p=0.014) 独立预测了MMSE得分.
- 这些发现突出了遗传学和大脑结构在认知功能中的相互作用.
结论:
- mtDNA D 分组和白质微观结构是老年人认知功能的调节者.
- 这项研究为认知衰老的生物学基础提供了新的见解.
- 需要进一步的研究来充分阐明这些复杂的机制.
更多相关视频
12:28Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
Published on: June 3, 2020
17.4K
09:38Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
Published on: November 14, 2017
15.0K
相关概念视频
01:37Mitochondria
13.7K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
13.7K
01:30Dementia
131
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
131
02:59Animal Mitochondrial Genetics
7.6K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
7.6K
01:30Cognitive Development During Adulthood
142
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
142
01:26Alzheimer's Disease: Overview
513
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
513