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提高黄素的物理化学稳定性和释放特性,使用 κ-黄素/贝水解剂水凝珠

Jia-Nan Yan¹, Yu-Qiao Wang², Zhu-Jun Zhang²

¹School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China; SKL of Marine Food Processing & Safety Control, National Engineering Research Center of Seafood, Collaborative Innovation Center of Seafood Deep Processing, Dalian 116034, China.

|September 23, 2023

概括

贝雄性性腺液化剂 (SMGHs) 和 κ-卡拉基 (KC) 珠子有效封装黄素 (Cur) 以持续释放和稳定保存30天.

科学领域:

生物材料科学生物材料科学
药物输送系统药物输送系统
海洋生物技术海洋生物技术

背景情况:

贝的雄性性腺解液 (SMGHs) 提供了一个新的生物材料来源.
κ-胡卜素 (KC) 是一个广泛用于封装的类化合物.
黄素 (Cur) 具有治疗性质,但面临生物可用性挑战.

研究的目的:

开发和描述SMGHs/KC/KCl珠子用于黄素封装.
研究SMGHs对珠子形态,黄素负载和释放动力学的影响.
为了评估黄素在开发的珠子中的稳定性.

主要方法:

用不同的SMGH:KC比率制造SMGH/KC/KCl珠.
使用SEM,FTIR光谱和T23放松时间测量的表征.
评估黄素加载效率和体外释放概况.
在4°C下30天内评估黄素保留率.

主要成果:

SMGHs/KC/KCl-Cur珠 (5:5比) 显示出最佳的球形形态和高黄素负载 (0.063 mg/0.1 g).
FTIR和放松时间数据证实了黄素在珠子矩阵中的成功捕获.
增加的SMGH含量导致网络收缩,孔径扩大,结构参数改变 (缺陷性).
珠子表现出持续的黄素释放 (大肠阶段约50%),以及高保留率 (>90%超过30天).

结论:

SMGHs/KC/KCl珠子是有效的封装黄素.
开发的珠子有助于持续释放黄素,并确保长期稳定性.
这种配方有望改善黄素的生物可用性和治疗应用.

关键词:

珠子珠子珠子库尔库明是一种黄素.保护保护保护贝贝贝贝贝贝贝是什么意思贝贝贝贝贝持续释放的持续释放 κ-Carrageenan 的意思是什么意思

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