新入院和住院精神病患者的高未识别的SARS-CoV-2暴露
K El Abdellati1, A Lucas2, H Perron3
1Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, Antwerp, Belgium; Scientific Initiative of Neuropsychiatric and Psychopharmacological Studies (SINAPS), University Psychiatric Centre Duffel, Duffel, Belgium.
Brain, behavior, and immunity
|September 23, 2023
概括
与医院工作人员相比,患有严重精神疾病的患者感染SARS-CoV-2的风险更高,血清流行率和暴露风险明显更高. 这凸显了在精神病医院加强感染控制的必要性.
科学领域:
- 传染病流行病学 传染病流行病学
- 精神病学护理 精神病学护理
- 免疫学 免疫学 免疫学
背景情况:
- 患有严重精神疾病 (SMI) 的患者面临SARS-CoV-2感染和不良结果的风险增加.
- 包括情绪和精神病谱系障碍在内的SMI与增加的死亡率有关.
- 尽管风险增加,但SMI患者在流行病暴露方面仍未得到充分研究,特别是在住院环境中.
研究的目的:
- 为了确定新入院精神病医院患者的SARS-CoV-2血清流行率和抗体标位.
- 在这个人群中量化促炎性细胞因子度.
- 使用可靠的多抗原评估,将患者的暴露与医院工作人员的暴露进行比较.
主要方法:
- 这是一项涉及285名精神病医院住院患者和192名医院护理人员的多中心,横截面研究.
- 针对多个病毒蛋白质的SARS-CoV-2抗体的定量评估使用先进的毛细血管西布洛特.
- 测量IL-6,IL-8和TNF-α细胞因子水平以及与血清状况的相关性.
主要成果:
- 与医院护理人员 (27.08%) 相比,精神病医院住院患者的SARS-CoV-2血清流行率显著更高 (67.85%).
- 患者的SARS-CoV-2暴露风险增加了2.51倍,抗体标位也更高.
- 患者的尖端蛋白位和IL-6/TNF-α水平显著更高,使他们与护理人员有所区别.
结论:
- 在精神病医院住院患者中,存在非常高的未被识别的SARS-CoV-2暴露率.
- 鉴于COVID-19在该人群中已知的不良结果,这一发现令人担忧.
- 加强传染病原体的监测和缓解策略对于精神病医院至关重要.
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