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解开自闭症谱系障碍中改变大脑功能连接的个人共享和个人特定子空间

Xiaolong Shan¹, Lucina Q Uddin², Rui Ma¹

¹Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China; Ministry of Education Key Lab for Neuroinformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu, China.

Biological psychiatry

|September 23, 2023

概括

这项研究表明,自闭症谱系障碍 (ASD) 中的功能连接性改变 (AFC) 有共同的和个人的模式. 专注于个体特定的大脑连接是理解ASD异质性和预测临床症状的关键.

科学领域:

神经科学是一个神经科学.
脑部成像脑部成像
自闭症谱系障碍研究研究

背景情况:

使用功能性磁共振成像 (fMRI) 的自闭症谱系障碍 (ASD) 研究面临因个体异质性而导致的可重现性挑战.
了解自闭症的神经基础需要方法来解释大脑连接的共同和独特变化.

研究的目的:

调查自闭症谱系障碍 (ASD) 中个体共享和个体特定的功能连接 (AFC) 的变化.
探索这些独特的连接模式如何与ASD的临床症状有关.

主要方法:

利用了来自自闭症脑成像数据交换的254名自闭症患者的静止状态fMRI数据和295名典型的发展控制数据.
采用常规直角基础提取来将AFC分解为个人共享和个人特定的子空间.

主要成果:

在个人共享子空间中确定了3个共同的组件,反映了组级的功能连接差异.
证明在个体特定子空间内的AFC显著改善了临床症状的预测.
发现了默认模式中的个体特异性AFC和带膜-眼膜网络之间的相关性,以及ASD中社交沟通缺陷和重复行为严重性的相关性.

结论:

将AFC分解为个人共享和个人特定的组件对于理解ASD异质性至关重要.
利用个体特定的大脑连接特征,为剖析复杂的神经发育障碍提供了一个有希望的方法.
开发的框架可以指导研究其他神经发育条件中的异质性.

关键词:

在 ASD 异质性.改变了功能连接的功能连接.常见的直角基础提取法

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