血液中的重金属与肺癌风险之间的关联:中国的一项病例对照研究
Kai Zhang1, Tengteng Zhu2, Xiaowei Quan2
1Hongqiao International Institute of Medicine, Shanghai Tongren Hospital and Faculty of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.
Chemosphere
|September 23, 2023
概括
这项研究发现,高血 (Mo) 增加了肺癌风险,而 (Se) 显示出保护作用. (Cd) 对抗了Se,突出了金属混合物在肺癌中的复杂作用.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 在瘤学瘤学.
背景情况:
- 肺癌与金属暴露有关,但金属的联合效应尚未得到充分研究.
- 研究金属混合物对于了解肺癌病因至关重要.
研究的目的:
- 探索金属混合物与肺癌风险之间的关系.
- 在肺癌队列中分析八种重金属的单独和综合作用.
主要方法:
- 86例肺癌患者和105例对照患者的血清样本使用ICP-MS分析了8种重金属.
- 使用了后勤回归,受限制的立方线,贝叶斯核机器回归 (BKMR),加权量子总和 (WQS) 和量子G计算 (QGC).
- 评估了剂量反应关系和混合物效应.
主要成果:
- 血中 (Mo) 度升高与肺癌风险增加有关 (OR=2.94).
- 较高的血 (Se) 度表明对肺癌有保护作用 (OR=0.18,p趋势<0.001).
- (Se) 和 (Cd) 对肺癌发生产生了对抗作用 (RERI=-0.95,AP=-0.95).
结论:
- (Se) 显示出在肺癌中抗癌应用的潜力.
- 防止 (Cd) 干扰 (Se) 的保护作用对于预防肺癌很重要.
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