有益或有害:由典型消毒剂及其混合物诱导的时间依赖性化,具有毒理相互作用
Meng-Ting Tao1, Shu-Shen Liu2, Zhong-Wei Gu3
1Key Laboratory of Yangtze River Water Environment, Ministry of Education, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, PR China; State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, PR China.
The Science of the total environment
|September 23, 2023
概括
消毒剂混合物可能会导致霍尔梅西斯,低剂量有有益作用. 这项研究揭示了组分霍梅西斯如何影响混合物效应和随时间的相互作用,强调了时间依赖分析的重要性.
科学领域:
- 环境毒理学环境毒理学
- 微生物学 微生物学
- 化学相互作用 化学相互作用
背景情况:
- 众所周知,消毒剂及其混合物会诱导霍尔梅西斯,这是一个双相剂量反应现象.
- 个人消毒剂成分及其混合物之间的抑制作用,以及这些混合物内的相互作用之间的关系仍然不太清楚.
研究的目的:
- 调查几个消毒剂及其混合物的依赖时间的发光抑制毒性.
- 用独立的行动模型评估消毒剂混合物的相互作用 (协同作用/对抗作用).
- 阐明消毒剂混合物中的霍尔梅西斯及其单个成分之间的相互关系.
主要方法:
- 在Vibrio qinghaiensis sp.-Q67 (Q67) 上在不同时间点 (0.25至12小时) 确定了化酸盐 (CSP),二甲基二甲基基氨基化物 (DOB),二甲基二甲基基氨基化物 (DOC),乙醇 (EtOH),甲基 (GLA),过氧化 (H2O2),异醇 (IPA) 和n-propanol (NPA) 的发光抑制毒性.
- 在四个系统中评估了20种混合组合 (EtOH-H2O2,DOB-H2O2,DOC-EtOH,EtOH-IPA-NPA).
- 开发了一个基于独立行动模型 (SAHmapIA) 的协同作用-对抗作用热图,以系统地分析混合物相互作用.
主要成果:
- 五种消毒剂 (CSP,EtOH,H2O2,NPA,IPA) 和17种混合物组合表现出时间依赖的.
- 混合物的催眠作用主要归因于其催眠成分.
- 大多数混合物在低度/剂量时表现出添加作用,在高度/剂量时表现出协同作用,随时间变化而变化.
结论:
- 该研究表明,在消毒剂混合物中观察到的霍尔梅斯与其单个成分之间的明显相互关系.
- 强调在评估消毒剂毒性和相互作用时考虑时间依赖的影响至关重要.
- 强调需要进一步调查消毒剂混合物引起的复杂相互作用.
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