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塑料液及其成分2,4-DTBP对斑马鱼胚胎早期发育的不良影响

Aifeng Li¹, Chen Yan², Jiangbing Qiu¹

¹Key Laboratory of Marine Environment and Ecology, Ocean University of China, Ministry of Education, Qingdao 266100, China; College of Environmental Science and Engineering, Ocean University of China, Qingdao 266100, China.

The Science of the total environment

|September 23, 2023

概括

塑料覆盖层液会损害斑马鱼的发育,增加死亡率和形. 虽然2,4-di-tert-butylphenol有所贡献,但它并不能完全解释在水生生物中观察到的毒性.

科学领域:

环境毒理学环境毒理学
水生生态毒理学水生生态毒理学
塑料污染研究塑料污染研究

背景情况:

塑料废弃物,特别是农业皮膜,通过液对水生生物构成环境风险.
从老膜中出的液体含有像2,4-di-tert-butylphenol (2,4-DTBP) 这样的化学物质,它是一种性抗氧化剂.
了解这些液的生态毒性对于评估水生生态系统的风险至关重要.

研究的目的:

调查农业化膜液对斑马鱼胚胎发育的不良影响.
为了确定和评估在液中发现的2,4-di-tert-butylphenol (2,4-DTBP) 的特定毒性.
阐明了斑马鱼观察到的发育毒性背后的分子机制.

主要方法:

斑马鱼胚胎生物毒性测试使用老化塑料液和分离的2,4-DTBP进行.
暴露评估包括死亡率,形,化率,心率和身体长度.
对暴露于2,4-DTBP的斑马鱼胚胎进行了转录组分析,以确定受影响的生物通路.

主要成果:

塑料液显著增加了斑马鱼胚胎死亡率和形率,同时降低了化率,心率和身体长度.
与液相比,2,4-DTBP对斑马鱼的发育有类似的,但不那么强烈的不良影响.
转录组分析显示,在暴露于2,4-DTBP的斑马鱼中,消化,胰腺分泌和代谢通路的显著下调,以及胆固醇代谢的上调.

结论:

农业塑料液对鱼类早期发育构成重大威胁,影响其生存和生长.
虽然2,4-DTBP有助于毒性,但液中的其他成分可能会加剧不良影响.
观察到的分子变化表明,斑马鱼幼虫暴露在塑料衍生化学物质中的消化能力和能量代谢受损.

关键词:

2,4-二三丁 (2,4-DTBP) 的使用情况胚胎的早期发展塑料添加剂塑料添加剂塑料浸剂的使用方法文字转录学 (Transcriptomics) 是一个学科.斑马鱼是一种斑马鱼.

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