相关实验视频
Updated: Jul 15, 2025

00:07
In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
Published on: August 23, 2019
7.4K
炎症性细胞因子调节的LNCPTCTS通过增强牛核出口来抑制甲状腺癌的进展
Chi Ma1, Nasha Zhang2, Teng Wang3
1Department of Thyroid Surgery, Yantai Yuhuangding Hospital, Shandong University, Yantai 264000, Shandong Province, China; Shandong University Cancer Center, Jinan 250117, Shandong Province, China.
Cancer letters
|September 23, 2023
概括
甲状腺癌扩散到淋巴结与抑制瘤 lncRNA (LNCPTCTS) 的表达减少有关. 炎症性细胞因子降低LNCPTCTS,促进癌症的进展和转移.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 淋巴结转移在癌症中很常见,导致癌症的进展和不良结果.
- 甲状腺癌经常转移到淋巴结,但潜在的机制尚未完全理解.
研究的目的:
- 为了研究表观遗传重编程在甲状腺癌淋巴结转移中的作用.
- 确定参与甲状腺癌进展和转移的新型分子参与者.
主要方法:
- 分析甲状腺癌组织和转移性淋巴结中的lncRNA表达.
- 通过炎症性细胞因子 (TNFα,CXCL10) 和转录因子 (EGR1) 调节LNCPTCTS的研究.
- 研究LNCPTCTS与eEF1A2和Snail的相互作用及其对Snail核出口和下游目标的影响.
主要成果:
- LNCPTCTS是一种新的抑制瘤的lncRNA,在甲状腺癌中显著减少表达,特别是在转移性淋巴结中.
- 炎症性细胞因子TNFα和CXCL10通过破坏EGR1与其促进体的结合来降低LNCPTCTS的表达.
- 丧失LNCPTCTS促进了牛核积累,抑制了E-cadherin和PEBP1,激活了上皮细胞-介质细胞过渡和MAPK信号传递.
结论:
- 一个新的范式将瘤微环境 (TME) 与甲状腺癌细胞中的表观遗传重编程联系在一起,驱动淋巴结转移.
- 作为一个关键的调节器,LNCPTCTS的作用是,其减少的表达促进了癌症的传播.
- 对于治疗甲状腺癌转移而言,LNCPTCTS代表了一个潜在的可针对性的漏洞.
相关概念视频
Regulation of Nuclear Protein Sorting
2.4K
Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
2.4K
lncRNA - Long Non-coding RNAs
8.6K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K
Synthesis and Regulation of Thyroid Hormones
4.7K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.7K
The Nucleolus
8.9K
The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
8.9K
Nuclear Export
3.7K
The nucleus restricts several proteins within and allows others to pass. The restricted proteins possess a nuclear retention sequence or NRS, anchoring them to the nuclear lamins and preventing their transport to the cytosol. The non-restricted proteins, after their synthesis, are transported to their site of action, such as the cytosol or other organelles, with the help of nuclear export signals or NES.
NES are of three types- the canonical 10-residue long leucine-rich signal and other...
NES are of three types- the canonical 10-residue long leucine-rich signal and other...
3.7K
Loss of Tumor Suppressor Gene Functions
4.9K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
4.9K

