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喷雾干燥的脂质纳米颗粒配方使mRNA的内内传递成为可能

Kristina Pagh Friis1, Sandra Gracin2, Steven Oag3

  • 1Advanced Drug Delivery, Pharmaceutical Sciences, R&D, AstraZeneca, Gothenburg, Sweden.

Journal of controlled release : official journal of the Controlled Release Society
|September 23, 2023
PubMed
概括

喷雾干燥可以提高脂质纳米粒子 (LNP) mRNA的稳定性,从而提高潜在的肺部输送. 这种新的配方克服了冷链储存的挑战,使得新的基于RNA的疗法,如疫苗和蛋白质替代疗法.

关键词:
药物输送是药物输送的过程.吸入式吸入方式脂质纳米颗粒的使用方法对于RNA疗法来说,它是一种治疗方法.喷雾干燥 喷雾干燥它们是mRNARNA.

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