酸盐和多囊性卵巢综合征 - 系统性文献综述
Roosa Neuvonen1, Marjo Huovinen1, David C Dorman2
1School of Pharmacy, University of Eastern Finland, Finland.
Reproductive toxicology (Elmsford, N.Y.)
|September 23, 2023
概括
产前暴露于酸盐,破坏内分泌功能的化学物质,显示出与多囊性卵巢综合征 (PCOS) 的不一致联系. 需要进一步的研究来澄清甲酸盐暴露与PCOS发展之间的关联.
科学领域:
- 内分泌学 在内分泌学.
- 环境健康 环境健康
- 生殖科学 生殖科学
背景情况:
- 多囊卵巢综合征 (PCOS) 是一种常见的内分泌疾病,受遗传和环境因素的影响.
- 酸盐是内分泌干扰化学物质,可能对女性生殖系统产生不良影响.
研究的目的:
- 系统地审查和评估产前甲酸盐暴露和PCOS发病率之间的关联.
主要方法:
- 在六个数据库中进行了系统的文献搜索.
- 纳入标准侧重于被诊断患有PCOS的女性人类,并暴露于甲酸盐.
- 七项研究 (六个病例控制,一个队列) 用JBI批判性评估工具进行了质量评估.
主要成果:
- 三项研究报告说,甲酸盐暴露和PCOS之间存在显著的积极关联.
- 两项研究发现了显著的负面关联,而两项研究发现没有关联.
- 没有出现一致的模式,但不排除酸盐对生殖和代谢系统的影响.
结论:
- 目前关于甲酸盐暴露和PCOS的证据是不一致的.
- 研究设计的局限性,例如从试管婴儿诊所招募参与者和年轻参与者的年龄,可能引入了偏见.
- 需要更严格的研究和更长的随访时间,才能确定酸盐和PCOS之间的明确联系.
相关概念视频
Oogenesis
63.8K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.8K
Disorders of the Female Reproductive System
393
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
393
Hormonal Regulation
33.2K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
33.2K
The Phosphorus Cycle
37.4K
Unlike carbon, water, and nitrogen, phosphorus is not present in the atmosphere as a gas. Instead, most phosphorus in the ecosystem exists as compounds, such as phosphate ions (PO43-), found in soil, water, sediment and rocks. Phosphorus is often a limiting nutrient (i.e., in short supply). Consequently, phosphorus is added to most agricultural fertilizers, which can cause environmental problems related to runoff in aquatic ecosystems.
37.4K
Gonadal and Placental Hormones
1.5K
The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
1.5K
Hormonal Control of the Ovarian Cycle
555
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
555


