口服的宿主导抗病毒药物,尼克洛萨米德,作为巧拉酸涂层纳米配方
Chongkai Zhai1, Mingda Wang2, Yanyan Jin3
1Department of Biomedical Sciences and Institute for Medical Science, Jeonbuk National University Medical School, Jeonju, Jeonbuk, South Korea; Animal Diseases and Public Health Engineering Research Centre of Henan Province, Luoyang Polytechnic, Luoyang, China.
International journal of antimicrobial agents
|September 23, 2023
概括
一种新的纳米配方增强了尼克洛萨米德的输送,改善了口服生物可用性和SARS-CoV-2治疗. 这一突破解决了难溶性候选药物的系统性输送挑战.
科学领域:
- 制药科学 制药科学
- 纳米技术 纳米技术
- 抗病毒药物开发 抗病毒药物开发
背景情况:
- 溶解度差阻碍了许多候选药物的系统输送.
- 尼克洛萨米德是一种抗病毒药物,由于口服生物可用性差,因此面临开发挑战.
- 有效的药物输送系统对于治疗成功至关重要.
研究的目的:
- 开发一种纳米配方,以增强尼克洛萨米德的全身输送.
- 为了提高尼古洛萨米德的口服生物利用率和治疗疗效.
- 提供一种解决方案,用于输送不易溶解的候选药物.
主要方法:
- 开发了一种用于非共价尼古拉胺和胆酸复合的纳米配方技术.
- 利用胆酸涂层的纳米颗粒通过内细胞和肠肝循环进行全身传递.
- 评估了尼古洛萨米德输送纳米颗粒 (NDN) 的口服生物利用率和血度.
主要成果:
- 尼古拉胺输送纳米颗粒 (NDN) 的口服生物可用性增加了八倍,达到38.3%.
- 尼克洛萨米德的血度达到1179.6 ng/mL,是治疗水平的11倍.
- 在动物模型中观察到的SARS-CoV-2临床症状的完全消失.
结论:
- 开发的纳米配方显著提高了尼克洛萨米德的口服生物可用性和治疗疗效.
- 这项技术提供了一个可行的解决方案,用于系统输送可溶性较差的抗病毒药物,如尼克洛萨米德.
- 纳米配方代表了治疗SARS-CoV-2和克服药物输送障碍的有希望的战略.
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