系统性比局部血液动力学-血管因素对静止状态的功能连接性的影响更大
Sebastian C Schneider1, Stephan Kaczmarz2, Jens Göttler3
1Technical University of Munich, School of Medicine, Klinikum rechts der Isar, Clinic for Psychiatry, Ismaningerstr. 22, 81675 Munich, Germany; Technical University of Munich, School of Medicine, Klinikum rechts der Isar, TUM Neuroimaging Center, Ismaningerstr. 22, 81675 Munich, Germany; Technical University of Munich, School of Medicine, Klinikum rechts der Isar, Department of Diagnostic and Interventional Neuroradiology, Ismaningerstr. 22, 81675 Munich, Munich, Germany.
像 perfusion 延迟这样的系统因素比局部因素更强烈地影响静止状态功能连接 (BOLD-FC). 在健康患者和ICAS患者的多模态MRI中的这一发现突显了血液供应对大脑活动模式的影响.
科学领域:
- 神经成像是一种神经成像.
- 脑血管生理学 脑血管生理学
- 功能性MRI分析
背景情况:
- 休息状态功能性MRI (BOLD-FC) 反映了神经元和非神经元过程,包括系统和局部血液动力学-血管影响.
- 现有研究经常研究单个因素,对它们对BOLD-FC的影响进行有限的综合和比较研究,特别是在人类中.
- 无症状的内动脉狭窄症 (ICAS) 提供了一个独特的模型来研究受损的血液动力学与保存的神经元功能.
研究的目的:
- 研究和比较不同系统和局部血液动力学-血管过程对同位素BOLD-FC的影响.
- 评估这些影响在健康对照组和单边无症状内动脉狭窄症 (ICAS) 患者中.
- 量化系统因素与局部因素对BOLD-FC差异的相对贡献.
主要方法:
- 采用多模态MRI方法,包括动态灵敏度对比 (DSC) MRI和伪连续动脉旋转标记 (pCASL).
- 测量了局部血液动力学指标:毛细血管过路时间异质性 (CTH),脑血体积 (CBV) 和脑血流量 (CBF).
- 测量系统指标:从DSCMRI的时间到峰值 (TTP) 和从fMRI的BOLD滞后,使用线性混合模型进行分析.
主要成果:
- 血液动力学-血管因素 (局部和全身) 解释了所有参与者的BOLD-FC变异的20%.
- 系统因素 (TTP,BOLD滞后) 对BOLD-FC变异的贡献大约是局部因素 (CTH,CBV,CBF) 的两倍.
- 总体而言,局部和全身血动力学-血管因素共同解释了BOLD-FC变异的40.7%.
结论:
- 血液供应的区域差异,特别是全身 perfusion 延迟,对 BOLD-FC 产生更大的影响,而不是局部神经血管合障碍.
- 这些发现强调了系统血液动力学在塑造休息状态大脑活动模式中的关键作用.
- 该研究为BOLD-FC在健康和脑血管疾病中的血液动力学-血管贡献提供了新的比较见解.
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