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益生菌可以缓解晚期怀孕和哺乳母猪的便秘和炎症
Teng Ma1,2,3, Weiqiang Huang1,2,3, Yalin Li1,2,3
1Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China.
NPJ biofilms and microbiomes
|September 23, 2023
概括
益生菌补充剂缓解了便秘,减少了孕母猪的炎症,改善了小猪的生长. 这与母猪的有益变化有关.
科学领域:
- 动物科学动物科学
- 肠道微生物组研究研究
- 生殖生理学 生殖生理学
背景情况:
- 在孕期晚期和哺乳母猪中,便秘和全身炎症会导致健康问题,并影响小猪的生存.
- 益生菌缓解这些情况并增强肠道运动性的精确机制尚未完全理解.
研究的目的:
- 为了研究益生菌补充剂对便秘,炎症和晚期怀孕母猪的小猪生长的影响.
- 阐明涉及肠道微生物组和代谢变化的潜在机制.
主要方法:
- 随机对照试验,74头母猪被分配到益生菌或对照组.
- 对母猪血清炎症标记物的分析 (IL-4,IL-10,IL-1β,IL-12p40,TNF-α).
- 评估小猪生长表现,母猪肠细菌和菌群以及便/血清代谢物.
主要成果:
- 益生菌治疗显著降低了母猪便秘和调节了血清炎症性细胞因子概况.
- 在益生菌组中观察到小猪每日增加和断奶体重的显著增加.
- 益生菌的使用改变了肠道微生物的组成和多样性,增加了有益的细菌和特定的代谢物,如便丁酸盐和酸盐.
结论:
- 益生菌补充剂有效地缓解便秘和系统性炎症在晚期怀孕母猪.
- 这些好处与肠道微生物组的有利转变,增强的代谢潜力和改善小猪生长有关.
- 这项研究提供了对猪生殖和健康中的益生菌疗效的机制性见解.
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