哺乳动物皮层中发育过程的非均时间缩放
Annalisa Paolino1,2, Elizabeth H Haines1,2, Evan J Bailey1,2
1The University of Queensland, School of Biomedical Sciences, Brisbane, QLD 4072, Australia.
Nature communications
|September 23, 2023
概括
大脑发育的时间有很大的不同. 比较小鼠和纳特,揭示了皮层发育过程的差异,特别是细胞迁移和轴突延伸,为哺乳动物大脑进化提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 发育生物学 发展生物学
- 比较解剖学的比较解剖学
背景情况:
- 大脑发育的时间在物种之间是高度可变的.
- 皮层发育过程在不同发育步伐的扩展方面还没有得到充分理解.
- 哺乳动物物种表现出不同的发育策略,尽管它们的大小相似.
研究的目的:
- 为了比较两个具有相似大小但不同发育步伐的哺乳动物皮层发育的时间:小鼠和肥尾.
- 调查皮层发育的不同过程如何在既定的发育时间框架内扩展.
- 了解哺乳动物皮层发育时间差异的进化影响.
主要方法:
- 皮层发育时间表的比较分析.
- 检查细胞的诞生,层状特征,迁移和轴突延伸.
- 细胞差异的识别,例如基底中间原生细胞.
主要成果:
- 细胞诞生和层状特异性显示小鼠和纳特在同等发育阶段之间的时间对齐.
- 皮层发育过程,如细胞迁移和轴突延伸,并不均地扩展,在纳特中更为先进.
- 纳特人表现出基底中间原生细胞的缺乏,这可能解释了时间差异.
结论:
- 皮层发育过程具有时间限制和相似大小的类哺乳动物之间的可塑性差异.
- 迁移和轴突延长时间的差异有助于大脑发育速度的变化.
- 这些发现为细微的时间变化提供了洞察力,这些变化推动了哺乳动物大脑的早期多样化.
相关概念视频
Cleavage and Blastulation
After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.
Parental Care
Many animals exhibit parental care behavior, including feeding, grooming, and protecting young offspring. Parental care is universal in mammals and birds, which often have young that are born relatively helpless. Several species of insects and fish, as well as some amphibians, also care for their young.
The Mammary Glands
The female breast is a hemispheric projection of variable size positioned anterior to the pectoralis major and serratus anterior muscles. A fascia layer composed of dense, irregular connective tissue connects it to these muscles.
Each breast features a pigmented projection known as the nipple, through which milk emerges via closely spaced openings of ducts, referred to as lactiferous ducts. Surrounding the nipple is a circular pigmented area of skin named the areola, which appears rough due to...
Each breast features a pigmented projection known as the nipple, through which milk emerges via closely spaced openings of ducts, referred to as lactiferous ducts. Surrounding the nipple is a circular pigmented area of skin named the areola, which appears rough due to...
Development of Human Microbiota
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...


