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葡萄糖-6-酸盐脱酶缺乏加速了糖尿病患者的动脉衰老
Angelo Scuteri1,2, Christopher H Morrell3, Majd AlGhatrif3,4
1Dipartimento Scienze Mediche e Sanita' Pubblica, Universita' di Cagliari, Cagliari, Italy. angelo.scuteri@unica.it.
Acta diabetologica
|September 23, 2023
概括
葡萄糖-6-酸脱酶缺乏 (G6PDd) 加快了糖尿病患者的动脉衰老. 这种缺乏与较高的炎症和动脉硬有关,即使与类似的葡萄糖水平.
科学领域:
- 心血管医学 心血管医学
- 代谢障碍 代谢障碍 代谢障碍
- 遗传学 遗传学是一种遗传学.
背景情况:
- 已知高葡萄糖水平和葡萄糖-6-酸脱酶缺乏 (G6PDd) 会导致组织炎症.
- 以硬化为特征的动脉衰老是心血管事件的重要危险因素.
研究的目的:
- 调查G6PDd是否会加剧糖尿病患者的动脉衰老.
- 在糖尿病人群中确定G6PDd,炎症和动脉硬之间的关联.
主要方法:
- 评估了血葡萄糖,介质素-6 (IL6) 水平和动脉-动脉脉脉波速度 (PWV),作为动脉硬度的衡量标准.
- 测量了4448名撒丁岛人的大量队列中的G6PD红细胞活性.
- 分析数据按糖尿病状态和G6PDd存在分层.
主要成果:
- 在糖尿病患者中,G6PDd与非G6PDd个体相比,与显著更高的IL6和PWV有关,尽管血葡萄糖水平相似.
- 具体来说,G6PDd糖尿病患者的PWV为8.0m/s,而非G6PDd糖尿病患者的PWV为7.2m/s.
- 与非G6PDd糖尿病患者 (4.2 pg/ml) 相比,G6PDd糖尿病患者 (6.9 pg/ml) 的中白素-6水平也升高.
- 在非糖尿病患者中,G6PDd没有显著影响快餐血葡萄糖,IL6或PWV.
结论:
- 糖尿病患者的葡萄糖-6-酸脱酶缺乏与炎症标志物增加有关.
- 在糖尿病的背景下,G6PDd与加速的动脉衰老和硬度有关.
- 这些发现突出了G6PDd和糖尿病在促进心血管风险方面的潜在相互作用.
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