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Updated: Jul 15, 2025

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
07:12

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets

Published on: April 16, 2015

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单细胞转录组学揭示了不同成熟阶段和人类胸膜不变天然杀手T细胞的亚系承诺

Kristina Maas-Bauer1,2, Natalie Köhler2,3, Anna-Verena Stell2

  • 1Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University, Center for Clinical Sciences Research Building, 269 W. Campus Drive, Stanford, CA 94305, United States.

Journal of leukocyte biology
|September 24, 2023
PubMed
概括

人类不变的自然杀手T细胞在胆髓中成熟,经历不同的阶段. 这项研究揭示了亚系承诺的证据,其中不成熟的细胞类似于iNKT2和成熟的细胞类型iNKT1.

关键词:
不同化的差异化差异化.人类不变的自然杀手T细胞iNKTT 在线观看 在线观看在iNKT子集.我们的 scRNAseqq.胸部发育 胸部发育 胸部发展

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An Optimized Method for Isolating and Expanding Invariant Natural Killer T Cells from Mouse Spleen09:01

An Optimized Method for Isolating and Expanding Invariant Natural Killer T Cells from Mouse Spleen

Published on: October 29, 2015

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Characterization of Thymic Settling Progenitors in the Mouse Embryo Using In Vivo and In Vitro Assays08:56

Characterization of Thymic Settling Progenitors in the Mouse Embryo Using In Vivo and In Vitro Assays

Published on: June 9, 2015

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Lineage Commitment

Commitment is the  process whereby stem cells:
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T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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