ADHD药物对受伤风险的影响:基于偏好的仪器变量分析
Tarjei Widding-Havneraas1,2, Felix Elwert3,4, Simen Markussen5
1Centre for Research and Education in Forensic Psychiatry, Haukeland University Hospital, Bergen, Norway. tarjei.widding-havneras@uib.no.
European child & adolescent psychiatry
|September 24, 2023
概括
注意缺陷/多动症 (ADHD) 增加了受伤的风险. 虽然ADHD药物没有显示出整体保护作用,但在某些年轻患者中,它可能会随着时间的推移减少急诊室的伤害.
科学领域:
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
- 药理学 药理学是指药理学的学科.
背景情况:
- 注意缺陷/多动障碍 (ADHD) 与受伤的风险更高有关.
- 对ADHD药物治疗对受伤风险的影响的因果证据有限.
研究的目的:
- 研究ADHD药物对年轻人受伤风险的因果影响.
- 为了确定ADHD药物是否影响需要急诊室或病房治疗的伤害发生率.
主要方法:
- 利用了挪威登记处对8051名被诊断患有多动症的患者 (年龄在5-18岁) 的数据.
- 使用仪器变量 (IV) 分析,使用ADHD药物供应商偏好来解决混问题.
- 在诊断后长达4年的时间里,跟踪了ADHD药物使用和受伤数据.
主要成果:
- 与一般人群相比,患有ADHD的个体的受伤风险增加了35% (RR 1.35).
- 患有ADHD的女性比男性 (RR 1.23) 有更高的受伤风险 (RR 1.47).
- 在较轻或不典型的ADHD病例中,ADHD药物对整体伤害没有发现因果保护作用,但随着时间的推移,观察到对急诊室伤害的潜在影响.
结论:
- 特别是在女性中,ADHD是受伤的重要危险因素.
- 对ADHD的药物治疗似乎不能在轻度或非典型症状的年轻患者中提供整体保护.
- 可能需要进一步的研究来探索ADHD药物对特定伤害类型和治疗设置的微妙影响.
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