根源性囊切除术后的长期功能和阴道管的形成
Julio Chevarria1, Chaudhry A Ebad2, Mairead Hamill2
1Department of Nephrology and Transplantation, Beaumont Hospital, Beaumont Road, Dublin, Ireland. jl.chevarria@gmail.com.
Irish journal of medical science
|September 24, 2023
概括
膀癌的激进囊切除术 (RC) 存在长期衰退和死亡风险. 年轻的年龄和较低的手术前eGFR与脏问题有关,而年龄较大和癌症晚期增加死亡风险.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 激进囊切除术 (RC) 是膀癌的主要治疗方法.
- 脊髓癌与显著的长期发病率有关,包括功能障碍和死亡率.
研究的目的:
- 确定RC后长期功能下降的危险因素.
- 为了确定RC后死亡率的风险因素.
主要方法:
- 对264名接受RC和尿路转移的患者 (1996-2016) 的回顾性研究.
- 在手术前和每年手术后评估估计的膜过率 (eGFR).
- 利用考克斯和细灰回归分析来确定风险因素.
主要成果:
- 康复后功能下降,5.3%需要透析,32.8%经历了>10毫升/分钟/1.73m2的eGFR下降.
- 年轻的年龄和较低的手术前eGFR是末期脏病 (ESKD) 的风险因素.
- 高龄,晚期瘤阶段 (T≥2) 和缺乏化疗与增加的死亡率有关.
结论:
- 接受RC治疗的患者面临着逐渐恶化的功能恶化和死亡率升高的风险.
- 年龄和手术前的EGFR是功能下降的关键风险因素.
- 定期监测功能对于早期诊断和管理至关重要.
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