怀孕中的高血压疾病在莫亚莫亚病:一个单一机构的经验
Hirohisa Yajima1, Satoru Miyawaki1, Seisuke Sayama2
1Department of Neurosurgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Tokyo 113-8655, Japan.
概括
在莫亚莫亚病 (MMD) 患者的怀孕显示出更高的妊娠高血压障碍 (HDP) 的频率. 严格的血压监测对于MMD患者在怀孕期间和产后至关重要.
科学领域:
- 神经学 神经学
- 产科 产科 产科 产科 产科
- 遗传学 遗传学 是一个
背景情况:
- 莫亚莫亚病 (MMD) 是一种罕见的脑血管疾病.
- 在MMD患者中,怀孕特征和分娩风险尚不清楚.
研究的目的:
- 为了研究患有莫亚莫亚病的患者的围产期结局.
- 评估MMD患者怀孕和分娩相关的风险.
主要方法:
- 在东京大学医院 (13个MMD怀孕的临床数据的回顾性审查 (2000-2021年).
- 分析母亲的特征,产科并发症,分娩方法,新生儿结果和神经事件.
- 包括RNF213变种在内的遗传分析.
主要成果:
- 在13个怀孕中,有7个怀孕经历了妊娠高血压障碍 (HDP).
- 五个怀有RNF213 p.Arg4810Lys变异的怀孕发生了HDP.
- 一次产后缺血性中风发生;没有报告新生儿不良后果.
结论:
- 妊娠高血压障碍 (HDP) 在MMD怀孕中更常见.
- 建议在怀孕期间和分娩后对MMD患者进行密切的血压管理.
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