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怀孕和自发的宫动脉剖析:一个倾向匹配的回顾性队列研究

Robert J Trager¹, Clinton J Daniels², Zachary E Scott²

¹Connor Whole Health, University Hospitals Cleveland Medical Center, Cleveland OH, USA.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

|September 24, 2023

概括

与非孕妇相比,孕妇自发宫动脉解剖 (sCeAD) 的风险增加了两倍. 这种增加的sCeAD风险会影响动脉或脊椎动脉,特别是在怀孕和产后期间.

科学领域:

神经学神经学
产科和妇科产科和妇科
血管外科血管外科

背景情况:

自发宫动脉解剖 (sCeAD) 是一种罕见但严重的疾病,影响着动脉或脊椎动脉.
孕妇患sCeAD的风险尚未得到充分确立.
了解与怀孕相关的血管事件风险对于母亲健康至关重要.

研究的目的:

为了调查怀孕妇女患sCeAD的风险增加的假设.
为了比较孕妇与非孕妇的sCeAD发病率.
为了确定与怀孕和产后期有关的sCeAD的时间.

主要方法:

一个大型的美国研究网络 (TriNetX) 数据库 (>111万患者,2008-2023) 被查询.
妇女分层分为怀孕 (第一季度超声波,分娩) 和非怀孕 (妇科检查) 队列.
对混变量进行控制的倾向匹配,对sCeAD的风险比率 (RR) 计算在一年的随访期间.

主要成果:

在怀孕队列中,sCeAD的发病率为每10万人/年8.0,而在非怀孕队列中为3.9.
孕妇患sCeAD的风险增加了两倍 (RR:2.06;95% CI:1.17-3.61;P=.0104).
在怀孕队伍中,大多数sCeAD病例发生在怀孕期间,而不是产后.

结论:

与非怀孕妇女相比,妇女在怀孕期间和产后期间患sCeAD的风险是怀孕期间和产后期间的两倍.
进一步的研究是有必要的,以探索母亲的共同疾病的作用,如孕前.
澄清sCeAD与怀孕相关的精确时间是必不可少的.

关键词:

内动脉剖析的内动脉剖析.分割的方法分割的方法怀孕怀孕怀孕怀孕脊椎动脉剖析脊椎动脉剖析

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