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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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长期暴露于空气污染,习惯性体力活动,以及发生的慢性病
Zhi-Hao Li1, Wei-Qi Song1, Cheng-Shen Qiu1
1Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China.
Ecotoxicology and environmental safety
|September 24, 2023
概括
身体不活动和空气污染增加慢性病 (CKD) 的风险. 然而,增加体力活动 (PA) 可以有助于降低CKD风险,无论空气污染水平如何,建议PA作为一个关键的预防策略.
科学领域:
- 环境健康 环境健康
- 腎臟病學 (nephrology) 是一種醫學專業.
- 流行病学 流行病学
背景情况:
- 空气污染和身体不活动都是慢性病 (CKD) 的确定的危险因素.
- 暴露于空气污染物可能会加剧CKD的风险,特别是在体力活动期间.
- 了解环境因素和生活方式选择之间的相互作用对于公共卫生战略至关重要.
研究的目的:
- 调查空气污染暴露和体力活动对发生事件CKD的风险的独立和联合影响.
- 评估特定空气污染物 (PM2.5,PM10,NO2,NOx) 和身体活动水平与CKD发病率之间的关联.
- 确定身体活动是否可以减轻与空气污染暴露相关的风险,与CKD相关.
主要方法:
- 来自英国生物库的367,978名参与者的分析,在基线 (2006-2010年) 没有CKD.
- 评估暴露于细颗粒物 (PM2.5,PM10),二氧化 (NO2) 和氧化 (NOx) 的情况.
- 身体活动水平是自我报告的,并使用Cox比例危险模型来评估事件CKD风险,平均随访时间为12.4年.
主要成果:
- 对PM2.5,PM10,NO2和NOx的高暴露与CKD风险增加 (11-15%) 有关.
- 中度和高水平的体力活动与降低CKD风险 (18-22%) 相关.
- 与低PA和高污染暴露 (HRs在0.69-0.71之间) 相比,高体力活动和低空气污染暴露的个体的发生性CKD风险明显较低.
结论:
- 减少空气污染暴露和增加体力活动都与较低的CKD风险独立相关.
- 身体活动可以作为CKD的一般预防措施,无论环境空气污染水平如何.
- 需要在中度至严重污染地区进行进一步的研究,以验证这些发现.
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