在阻塞性睡眠呼吸暂停中,氨基酸负担,低氧化,睡眠结构和认知之间的关联
Marina G Cavuoto1,2, Stephen R Robinson2,3, Fergal J O'Donoghue2,4
1Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Clayton, Australia.
Journal of Alzheimer's disease : JAD
|September 24, 2023
概括
阻塞性睡眠呼吸暂停 (OSA) 与大脑粉样蛋白负担增加和认知能力下降有关. 夜间低氧化症是OSA的一个关键特征,与粉样蛋白负担和记忆障碍有关,这表明它可能在痴呆症的发展中起作用.
科学领域:
- 神经科学是一个神经科学.
- 睡眠医学 睡眠医学
- 老年学是一门学科.
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 越来越多地被认为与粉样β (Aβ) 负担的增加有关,这是阿尔茨海默病的主要生物标志物.
- 喘也与认知能力下降有关,这引发了关于潜在机制的问题.
- 在OSA中睡眠障碍与神经退行过程之间的相互作用需要进一步阐明.
研究的目的:
- 调查低氧化和慢波睡眠中断对OSA患者大脑Aβ负担的明显影响.
- 检查低氧症,慢波睡眠障碍和Aβ负担如何影响OSA患者和健康对照者的认知功能.
- 确定在OSA中与睡眠相关的特定因素,这些因素有助于Aβ积累和认知障碍.
主要方法:
- 34名OSA患者和12名健康对照者的队列接受了多睡眠学和NAV4694正子发射断层扫描 (PET) 扫描,以量化Aβ负担.
- 对所有参与者进行了APOEε基因型和综合认知评估.
- 使用线性等级回归分析来评估人口统计,睡眠和Aβ变量与认知结果之间的关系.
主要成果:
- 在OSA组中发现了Aβ负担和夜间低氧症之间的显著关联.
- 无论是Aβ负担还是低氧症都与特定的认知缺陷有关,包括语言情节性记忆,自传记忆和设置转移受损.
- 即使在控制睡眠变量后,设置转换性能仍然与Aβ负担有显著的关联,而低氧症与自传记忆障碍相关.
结论:
- 夜间低氧症在OSA中与大脑Aβ负担直接相关.
- 低氧症和Aβ负担对认知功能产生不同的影响.
- 这些发现强调低氧化症是痴呆症发展的潜在因果因素,也是OSA患者痴呆症预防的潜在治疗目标.
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