早期帕金森症的睡眠障碍:一个基于人口的研究
Stuart J McCarter1,2, Emanuele Camerucci1, Aidan F Mullan3
1Mayo Clinic Department of Neurology, Rochester, MN, USA.
Journal of Parkinson's disease
|September 24, 2023
概括
睡眠障碍在早期发病的帕金森症中很常见,类似于典型发病的病例. 然而,失眠在运动症状出现后的早期发病组中更频繁地发生.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 流行病学 流行病学
背景情况:
- 睡眠障碍在帕金森症中很普遍.
- 睡眠障碍对早期发病的帕金森症的影响与典型发病病例相比仍然不清楚.
研究的目的:
- 为了比较睡眠障碍的患病率和发病率在运动症状发作之前和之后.
- 为了区分早期发病的帕金森症 (年龄 ≤50岁) 和典型发病的帕金森症 (年龄 >50岁) 之间的睡眠障碍模式.
主要方法:
- 基于人口的队列研究 (1991-2015年) 涉及38名早期发病和1001名典型发病的帕金森症患者.
- 检查了医疗记录,检查睡眠障碍的存在,类型和与运动症状的关系.
- 逻辑回归和考克斯的比例危险模型分析了睡眠障碍的发病前和后的睡眠障碍率.
主要成果:
- 在帕金森症发作之前,睡眠障碍的患病率相似 (24%对16%).
- 发病后的发病率是可比的 (5.85对每100人年4.11例).
- 早期发病的帕金森氏症显示,运动后失眠的风险更高 (HR 1.73).
结论:
- 睡眠障碍在早期发病的帕金森症中很常见,发生的总体频率与典型发病的帕金森症相似.
- 失眠是一个显著的例外,在运动症状出现后的早期发病组中更为频繁.
- 这些发现突显了早期帕金森症中睡眠障碍的特定风险.
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