微生物对引发和治疗宿主癌症的影响:肠道屏障视角
Henan Zhang1, Junrui Wu2, Na Li3
1College of Food Science, Shenyang Agricultural University, Shenyang 110866, PR China; Engineering Research Center of Food Fermentation Technology, Shenyang 110161, PR China.
Biochimica et biophysica acta. Reviews on cancer
|September 24, 2023
概括
炎症性肠病 (IBD) 的并发症可能涉及瘤. 恢复肠道屏障功能和微生物群平衡是预防由炎症驱动的癌症的关键.
科学领域:
- 胃肠道学和瘤学
- 微生物组研究 微生物组研究
- 免疫学 免疫学 免疫学
背景情况:
- 炎症性肠病 (IBD) 呈现复杂的并发症,可能导致瘤.
- 关于由炎症驱动的慢性免疫疾病和癌症病原发生的研究有限.
- 肠道微生物群的不平衡通常伴随着肠道炎症,延迟恢复并加剧系统性问题.
研究的目的:
- 审查肠道屏障破坏,微生物转移及其对大脑,肝脏和肺部等器官的影响之间的联系.
- 探索这些因素在瘤发作中的作用.
- 要突出肠道微生物群,免疫监测和炎症中肠道屏障修复之间的联系.
主要方法:
- 文献综述侧重于肠道屏障完整性,微生物转移和炎症诱导的病理.
- 分析肠道微生物群在免疫监测和肠道修复中的作用.
- 检查饮食干预措施,特别是抗炎饮食,以控制炎症和屏障功能.
主要成果:
- 肠道屏障破坏和微生物转移有助于全身炎症和多器官病理.
- 这些因素都与瘤的发病有关.
- 肠道微生物群和屏障状态对于免疫监测和炎症控制至关重要.
结论:
- 提高肠道屏障功能是预防和治疗慢性恶性瘤的潜在策略.
- 部分抗炎饮食可以通过修复肠道屏障和减少炎症来预防恶性转变.
- 恢复肠道微生物群平衡对于缓解炎症和相关病理至关重要.
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