在慢性乙型肝炎中,NAFLD与较不严重的肝纤维化有关:一个多中心的回顾性研究
Renling Yao1, Sufang Lu1, Ruifei Xue2
1Department of Infectious Diseases, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.
Annals of hepatology
|September 24, 2023
概括
非酒精性脂肪性肝病 (NAFLD) 影响近20%的慢性乙型肝炎 (CHB) 患者. 重要的是,在这些患者中,NAFLD似乎与较不严重的肝纤维化有关.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 内部医学 内部医学
背景情况:
- 慢性乙型肝炎 (CHB) 可以发展为严重的肝病.
- 非酒精性脂肪性肝病 (NAFLD) 通常与CHB同时发生.
- 对NAFLD对CHB相关纤维化进展的影响进行了辩论.
研究的目的:
- 为了确定CHB患者中NAFLD的患病率.
- 在CHB患者中调查NAFLD和肝纤维化严重程度之间的关联.
主要方法:
- 对曾经接受过肝活检的未经治疗的CHB患者的回顾性分析.
- 倾向性得分匹配 (PSM) 控制NAFLD和没有NAFLD的群体之间的混因素.
主要成果:
- 在1496名CHB患者中,NAFLD被诊断为19.4%的患者.
- 与没有NAFLD的CHB患者相比,NAFLD患者的显著,晚期纤维化和肝硬化率明显较低.
- 在PSM之后,NAFLD仍然是抗CHB患者显著和晚期肝纤维化的独立保护因素.
结论:
- 在CHB患者中,NAFLD很普遍 (19.4%).
- 在CHB患者中,NAFLD与肝纤维化严重程度的降低有关.
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