执行功能轨迹及其与精神分裂症和非精神病学比较参与者的炎症生物标志物的潜在关联
David H Adamowicz1, Tsung-Chin Wu2, Rebecca Daly3
1Mass General Brigham, Department of Psychiatry, Division of Geriatric Psychiatry, Brigham and Women's Hospital, 60 Fenwood Road, Boston, MA 02115, USA; Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.
精神分裂症的认知衰退没有被炎症标志物预测出来. 实践效应显示,高学历人士的执行功能下降,无论诊断如何.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 认知障碍是精神分裂症的核心特征,影响日常功能.
- 关于精神分裂症认知轨迹的先前研究受到实践效应和短暂的随访时间的限制.
- 了解炎症在认知变化中的作用对于开发有针对性的干预措施至关重要.
研究的目的:
- 检查精神分裂症 (PwS) 患者的执行功能轨迹与随时间推移的比较参与者 (NCs).
- 调查基线炎症生物标志物与执行功能变化之间的关联.
- 在纵向认知评估中控制实践效应.
主要方法:
- 在7次访问 (平均随访时间为4.4年) 中,对350名参与者 (186名PWS,164名NC) 进行了执行功能评估.
- 测量了基线的炎症生物标志物:hs-CRP,干扰素-,TNF-α,IL-6,IL-8和IL-10.
- 使用线性混合效应模型来分析轨迹和炎症预测,控制共变量.
主要成果:
- 执行功能改善在普华永道和老年人中减弱.
- 对实践效应的控制显示,无论诊断如何,受过高等教育的参与者数量都在下降.
- 较高的基线hs-CRP仅在NC中预测了更差的执行功能;TNF-alpha在控制实践效果后预测了变化.
- 只有hs-CRP在经过多次比较调整后,对执行职能产生了显著的主要影响.
结论:
- 基线系统性炎症没有预测PWS或NCs的纵向执行功能下降.
- 需要进一步的研究来阐明在精神分裂症中炎症和认知之间复杂的时间关系.
- 研究炎症和认知过程之间的动态相互作用对于理解精神分裂症病理生理学至关重要.
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