在中国人口中,多种金属暴露与睡眠障碍之间的关联:一种基于混合的方法
Lu Yufu1, Liu Qiumei1, Zhang Tiantian1
1School of Public Health, Guangxi Medical University, Shuangyong Road No.22, Nanning, 530021, Guangxi, China.
Chemosphere
|September 24, 2023
概括
这项研究发现, (Zn) 和 (Mg) 的较高水平与睡眠障碍的风险降低有关. 多种金属的联合作用也显示出对睡眠障碍的保护性关联.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 睡眠医学 睡眠医学
背景情况:
- 新出现的证据表明,金属暴露与睡眠障碍之间存在联系.
- 了解 (Zn),铜 (Cu), (Se), (Mg) 和 (Ca) 等必需矿物质在睡眠健康中的特定作用至关重要.
研究的目的:
- 调查单次和同时暴露的Zn,Cu,Se,Mg和Ca与睡眠障碍的风险之间的联系.
- 阐明这些金属与睡眠健康有关的复杂相互作用.
主要方法:
- 采用后勤回归,受限立方线 (RCS),量子g计算 (Q-gcomp),加权量子总和 (WQS) 和贝叶斯内核机器回归 (BKMR) 模型.
- 分析了与睡眠障碍患病率相关的五种金属 (Zn,Cu,Se,Mg,Ca) 的血水平.
主要成果:
- 高度的 Zn 与四分位数中睡眠障碍的风险较低显著相关.
- 特定的组合,包括Zn/Cu和Zn/Se,以及Mg/Ca,也表明风险降低.
- 多金属分析表明,对睡眠障碍的总体负面影响,Zn是最有影响力的贡献者.
结论:
- 血中Zn,Mg和特定金属组合 (Zn/Cu,Zn/Se,Mg/Ca) 的含量与睡眠障碍的风险降低有关.
- 对多种金属的联合暴露对睡眠障碍产生保护作用,主要是由驱动的.
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