人参药物具有不同性质的机制在甲状腺功能增强症上的差异
Linlin Liu1, Xueying Han1, Guoshun Shan2
1Department of Chinese Medicine Chemistry, Liaoning University of Traditional Chinese Medicine, Dalian, China.
Journal of ethnopharmacology
|September 24, 2023
概括
这项研究表明,人参药物,包括红人参和黑人参 (RG和BG),通过调节关键的激素轴和肠道微生物群来治疗甲状腺功能障碍. 黑人参表现出温和温和的性质,而具有寒冷性质的人参叶 (GL) 在甲状腺功能障碍治疗中最有效.
科学领域:
- 综合医学和药理学 综合医学和药理学
- 传统中国医学 (TCM) 疗效评估
- 内分泌学和新陈代谢研究研究
背景情况:
- 药用性质是评估草药疗效的关键TCM指数,甲状腺功能增高症 (qi-Yin缺乏综合征) 被归类为热症综合征.
- 人参品种 (GS,RG,BG) 和人参叶 (GL) 是具有独特药用性质的气调草药,适合研究大自然与 tonifying 作用之间的联系.
- 了解这些机制可以完善使用人参为基础的疗法,治疗甲状腺功能障碍等疾病.
研究的目的:
- 研究具有不同药用性质的人参药物的气调作用背后的独特机制.
- 为了比较不同人参制剂对甲状腺功能增强症的影响.
- 阐明黑人参 (BG) 的特定药用性质.
主要方法:
- 在使用Euthyrox的老鼠中诱导甲状腺功能过高.
- 从下丘脑-垂体-上腺 (HPA) 和淋巴腺 (HPG) 轴的类固醇被使用UPLC-QqQ-MS/MS量化.
- 分析了血清循环核酸系统,PI3K/Akt信号通路,肠道微生物群 (16S rDNA测序) 和短链脂肪酸 (SCFA通过GC-MS).
主要成果:
- GS,RG和BG通过调节下丘脑 - 下垂体 - 甲状腺 (HPT) 轴在治疗甲状腺功能过高的老鼠方面表现出有效性.
- RG显著调节HPA和HPG轴,而BG主要影响HPG轴;GL强烈影响HPA,HPG和HPT轴.
- GS调节了肠道Firmicutes/Bacteroides比率,GS,RG和BG改善了甲状腺功能障碍症中SCFA的减少;PCA表明BG的温和性质,类似于GS.
结论:
- 黑人参 (BG) 具有温和温和的性质,而人参叶 (GL) 具有寒冷的性质,对于甲状腺功能障碍治疗最有效.
- 人参药物在缓解甲状腺功能障碍时的气调效应涉及HPT,HPA和HPG轴.
- 循环腺单酸盐 (cAMP) /循环单酸盐 (cGMP),乙胆化酶 (AchE) 和 Na+-K+-ATPase/PI3K/AKT 途径作为评估 qi 调药物的性质的潜在生物标志物.
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