基于pH敏感的聚合物载体 - - 种子粘液/β-环氧/Mmt-Na+-co-poly (甲基酸盐) - - 用于可控输送capecitabine
Tahira Yasmin1, Asif Mahmood2, Muhammad Farooq1
1Faculty of Pharmacy, The University of Lahore, Punjab, Lahore, Pakistan.
International journal of biological macromolecules
|September 24, 2023
概括
使用子种子粘液和β-Cyclodextrin的新型pH响应性水凝增强了capecitabine的输送,提高了疗效,减少了用于癌症治疗的剂量频率.
科学领域:
- 材料科学 材料科学 材料科学
- 聚合物化学 聚合物化学
- 制药科学 制药科学
背景情况:
- 卡佩奇他具有一些缺点,如高剂量频率,短半衰期和低生物可用性.
- 开发先进的药物输送系统对于提高癌症治疗疗效至关重要.
- 响应pH的水凝具有控制药物释放的潜力.
研究的目的:
- 开发子种子粘液和基于β-Cyclodextrin的pH调节的水凝,用于持续释放capecitabine.
- 为了克服传统卡佩奇他的局限性.
- 创建一个生物相容和安全的药物输送系统.
主要方法:
- 使用水性自由基聚合来合成水凝.
- 描述包括热分析,FTIR,XRD,元素分析,SEM,胀和体外释放研究.
- 纳米复合物水凝是通过将含有卡佩西塔的粘土加入来制备的.
主要成果:
- 成功形成了热稳定,pH响应的交联网络.
- 水凝显示高平衡膨胀 (67.9892.98%在pH7.4) 和凝含量 (65.8893.56%).
- 纳米复合水凝显示持续释放capecitabine (30小时后比水凝长80.02%),改善了药物动力学参数.
结论:
- 开发的pH响应性水凝和纳米复合物水凝有效地维持了capecitabine的释放.
- 该系统显示了改善capecitabine疗效和减少癌症治疗中剂量频率的潜力.
- 毒性分析证实了开发系统的安全性,无毒性和生物相容性.
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