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Updated: Jul 15, 2025

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
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免疫球蛋白可变域框架区域的序列耐受性与非正规的内域二硫化物链接

Dae Young Kim1, Hiba Kandalaft1, Michael J Lowden1

  • 1Life Sciences Division, Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, Canada.

The Journal of biological chemistry
|September 24, 2023
PubMed
概括

在免疫球蛋白可变域中设计的非正规的二硫化物链接增强了稳定性和蛋白酶抵抗性. 这些在人类中缺少的新型链接与抗原结合相容,并改善蛋白质折叠.

关键词:
硫化二氧化物是什么?免疫球蛋白可变领域的免疫球蛋白.菌体显示器可以显示菌体.蛋白质工程工程 蛋白质工程蛋白质的稳定性 蛋白质的稳定性一个域抗体 (sdAb,纳米体)

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