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SUMOylation间接抑制了肠道上皮细胞中HIF-1α通路的活性

Mykyta I Malkov1, Darragh Flood1, Cormac T Taylor1

  • 1Conway Institute of Biomolecular and Biomedical Research and School of Medicine, University College Dublin, Belfield, Ireland.

The Journal of biological chemistry
|September 24, 2023
PubMed
概括

SUMOylation间接抑制了缺氧诱导因子1-alpha (HIF-1α) 在肠道细胞中的稳定性和活性. 抑制SUMOylation可以提高HIF-1α水平和转录活性,从而揭示出一种新的调节机制.

关键词:
缺氧 缺氧是指缺氧的情况.缺氧诱导因子的诱导因子肠道上皮质 肠道上皮质一个小的,类似于ubiquitin的修饰剂.化和化 化和化

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