基于脂质的营养补充剂用于预防儿童营养不良:当更少时,可能会更多
Kathryn G Dewey1, Charles D Arnold1, K Ryan Wessells1
1Institute for Global Nutrition and Department of Nutrition, University of California, Davis, Davis, CA, United States.
The American journal of clinical nutrition
|September 24, 2023
概括
中量脂基营养补充剂 (MQ-LNS) 在至少六个月内提供时,对儿童消耗和体重对长度z-scores有好处. 然而,MQ-LNS与少量脂质基营养补充剂 (SQ-LNS) 相比,没有提供额外的增长益处.
科学领域:
- 营养科学 营养科学
- 公共卫生 公共卫生
- 儿科 儿科 儿科
背景情况:
- 基于脂质的少量营养补充剂 (SQ-LNS) 是为了预防儿童营养不良而建立的.
- 关于中量脂基营养补充剂 (MQ-LNS) 对生长效应的证据有限.
- 之前的元分析表明,SQ-LNS改善了长度对年龄z-score (LAZ) 和体重对长度z-score (WLZ),减少了衰老和浪费.
研究的目的:
- 评估预防性MQ-LNS (250-499 kcal/d) 对6-23个月龄的儿童生长的影响.
- 为了比较MQ-LNS与没有补充剂和SQ-LNS的影响.
- 分析增长结果,包括WLZ,LAZ,浪费和衰退.
主要方法:
- 对营养补充剂的MQ-LNS研究进行系统审查.
- 基于补充剂持续时间 (<6个月与≥6个月) 的研究分类.
- 对≥6个月补充剂的研究进行元分析,重点关注WLZ,LAZ的变化以及消耗和衰退的流行情况.
主要成果:
- 短期MQ-LNS (<6个月) 显示出不一致的生长效应.
- 长期MQ-LNS (≥6个月) 在元分析中 (n=13,954) 改善了WLZ (+0.09) 和减少消耗 (0.89).
- 没有观察到长期MQ-LNS对LAZ或衰老有重大影响;与SQ-LNS相比,没有发现差异.
结论:
- 提供≥6个月的MQ-LNS可以改善体重与长度的z分数,并减少儿童的消耗.
- 目前的证据表明,MQ-LNS不会比SQ-LNS提供增长效益.
- 建议进行进一步的研究,比较MQ-LNS和SQ-LNS,并可能调查营养摄入的完整性.
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