pyrifos对环境的影响:对水生生物的跨代毒性影响不能被忽视
Junguo Ma1, Penglin Zhu1, Wenhua Wang1
1College of Life Science, Henan Normal University, Xinxiang, Henan 453007, China.
The Science of the total environment
|September 24, 2023
概括
成年斑马鱼的慢性pyrifos (CPF) 暴露导致父母转移和生殖毒性,影响F1后代的生存和健康. 这突显了水生环境中CPF污染带来的生态风险.
科学领域:
- 环境毒理学环境毒理学
- 水生生态毒理学 水生生态毒理学
- 生殖毒理学 生殖毒理学
背景情况:
- pyrifos (CPF) 是一种在自然环境中广泛使用的杀虫剂.
- 对水生物种和环境问题的潜在健康风险与CPF有关.
- 关于CPF对水生生物后代的跨代毒性影响的研究有限.
研究的目的:
- 调查CPF对成年斑马鱼 (F0) 生殖能力的慢性影响.
- 为了确定父母CPF暴露对F1和F2后代的影响.
- 评估CPF从父母转移到后代及其下游后果.
主要方法:
- 成年斑马鱼 (F0) 长期暴露于CPF (3和60μg/L).
- 在F0卵巢和F1胚胎/幼虫中分析CPF的存在.
- 评估F0生殖参数 (卵细胞发育,卵子生产).
- 斑马鱼的转录基因分析 (RNA-seq)
- 评估F1和F2后代的生存率,心率和生物化学指标.
主要成果:
- 在F0卵巢和F1后代中检测到CPF,证实了父母的转移.
- 暴露于CPF损害了F0雌性生殖能力 (卵细胞成熟,卵子生产).
- 父母的CPF暴露抑制了F1幼虫的心率,增加了F1死亡率,并改变了生化标志物 (氧化应激,炎症,亡).
- 转录基因分析显示,F1幼虫的ROS代谢,免疫功能,亡和代谢途径受到干扰.
结论:
- 长期暴露于CPF会导致斑马鱼的生殖毒性.
- 父母转移CPF到后代发生在鱼类中.
- 跨代对F1代生存和基因表达的影响引发了生态方面的担忧.
- 由于其跨代影响,CPF在水生环境中构成重大生态风险.
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