碳黑诱导的肺部疾病中的 lysosomal 功能障碍
Mingtong Gao1, Xiao Ge2, Yun Li1
1School of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Road, Qixia District, Nanjing, Jiangsu 210023, China.
The Science of the total environment
|September 24, 2023
概括
碳黑 (CB) 颗粒通过影响 lysosomes 引起肺损伤. 化溶解体或使用来自Nelumbinis plumula的neferine可以防止这些与污染相关的肺部疾病.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 细胞生物学 细胞生物学
背景情况:
- 碳黑 (CB) 是颗粒污染的主要组成部分.
- CB暴露与与肺相关的重大健康问题有关.
研究的目的:
- 研究聚合CB对肺组织和细胞的有害影响.
- 探索CB诱导的肺损伤的机制,专注于溶酶体.
- 评估neferine对CB毒性的保护潜力.
主要方法:
- 在体外和体内使用肺组织和膜上皮细胞的研究.
- 对炎症,亡和纤维化标志物的分析.
- 评估细胞活力,细胞死亡和反应性氧物种的产生.
- 对溶酶体膜透和化的研究.
主要成果:
- 在体内,CB暴露引起了炎症,亡和纤维化.
- 在体外,CB降低了细胞活力,增加了细胞死亡和氧化应激.
- CB 向溶酶体,导致膜透.
- 溶解体化减少了CB的有害影响.
- 尼费林证明了对CB诱导的肺损伤的保护作用.
结论:
- 通过 lysosomal 损伤,CB 颗粒诱导肺部疾病.
- 溶解体功能调节为CB诱导的肺病提供了潜在的治疗策略.
- 尼费林为与污染相关的肺部疾病提供了一个有前途的治疗剂.
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