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Brain Imaging

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...

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Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

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闭环大脑刺激闭环大脑刺激

Christoph Zrenner¹, Ulf Ziemann²

¹Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Institute for Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada; Department of Neurology & Stroke, University of Tübingen, Tübingen, Germany.

Biological psychiatry

|September 24, 2023

概括

使用实时脑电图 (EEG) 和跨磁刺激 (TMS) 的大脑状态依赖刺激,提供了一种修改大脑电路的新方法. 这种闭环方法承诺比固定协议更有效地治疗神经系统疾病.

关键词:

大脑状态大脑状态闭环刺激是一种闭环刺激.这是一个EEGEEGEEGEEGEEGEEGEEG.实时实时的时间.在TMSMS中使用.

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科学领域:

神经科学是一个神经科学.
神经技术的神经技术
计算精神病学是一种计算精神病学.

背景情况:

传统的大脑刺激使用固定的协议,忽视大脑的动态状态.
最近的进展允许使用脑电图 (EEG) 实时预测大脑状态.

研究的目的:

审查人类大脑状态依赖刺激的证据.
讨论EEG信息的跨磁刺激 (TMS) 治疗大脑疾病的潜力.
探索从开环到闭环大脑刺激的转变.

主要方法:

利用对EEG时间序列数据的前算法,以毫秒精度预测大脑状态.
应用EEG信息的跨磁刺激 (TMS) 来准特定的大脑状态.
调查临床前和系统水平的人类皮质证据.

主要成果:

临床前研究表明,通过特定状态的刺激,通过持续的电路修改 (例如,长期的强化).
有证据表明,这种方法在人类皮质层面是可行的.
实时EEG-TMS允许记录刺激效应,从而实现适应性协议.

结论:

大脑状态依赖性刺激代表了转向更加个性化和有效的神经调节的范式转变.
闭环系统为修改病态大脑网络提供了增强的潜力,例如在严重抑郁症中.
未来的研究应该专注于优化这些适应性刺激策略,以获得最大的治疗效益.