异性食道炎 (I-SEE) 严重程度指数反映了儿童的长度临床病理学变化
Andrew Dickerson1, Ayse Kolemen2, Keeler Kime2
1Division of Allergy and Immunology, Department of Pediatrics, University of California San Diego and Rady Children's Hospital, San Diego, California; Division of Gastroenterology, Department of Pediatrics, University of California San Diego and Rady Children's Hospital, San Diego, California.
概括
酸性食道炎的严重程度指数 (I-SEE) 有效地追踪了儿童随着时间的推移而患病的严重程度. 这一指标随着治疗的增加而有所改善,与更好的临床结果相关,如改善养和减少纤维化.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 埃索诺菲尔性食道炎的研究研究
- 疾病严重程度指标 疾病严重程度指标
背景情况:
- 湿性食道炎的严重程度指数 (I-SEE) 是一种新的评分系统.
- 在儿科队列中对I-SEE的纵向数据有限.
- 了解I-SEE的响应能力对于临床管理至关重要.
研究的目的:
- 在长线儿科队列中评估I-SEE分数.
- 评估I-SEE与EoE儿童的临床特征之间的关系.
- 为了确定I-SEE对常规护理治疗的反应能力.
主要方法:
- 预先注册的儿科队列的回顾性分析.
- 在诊断和随访内镜 (平均6.6年) 中计算的I-SEE.
- 分析临床,内镜和组织学特征,包括症状和BMI.
主要成果:
- 在基线时,43%的I-SEE得分轻度,36%的中度和21%的严重.
- 平均I-SEE显著下降,从第一次随访时的9.7降至最后一次随访时的3.9 (P < .001).
- 严重的基线I-SEE与低BMI和营养不良相关,随着时间的推移,这些情况有所改善. 纤维化也得到改善 (P < .01).
结论:
- I-SEE 是对接受长期治疗的EoE儿童的响应性严重性指标.
- 基线I-SEE得分与特定的临床特征相关,如BMI和食困难.
- I-SEE有助于监测儿科埃索诺菲尔食道炎的治疗有效性.
相关概念视频
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