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便免疫化学试验的诊断性能,用于检测在监视结肠镜时的高级新生病

Grace Berwald¹, Graeme P Young², Charles Cock³

¹Department of Medicine, College of Medicine and Public Health, Flinders University, Bedford Park, South Australia, Australia.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

|September 24, 2023

概括

一个2样便免疫化学测试 (FIT) 可以帮助优先考虑患者进行监视结肠镜检查. 这种方法有助于识别晚期瘤 (AN) 患者,优化医疗资源的使用.

科学领域:

胃肠病学胃肠病学
在瘤学瘤学.
医学诊断医学诊断医学诊断

背景情况:

医疗保健资源紧张导致结肠镜检查积压.
延迟监测结肠镜检查可能会对结肠直肠癌 (CRC) 高风险个体造成伤害.
一个2样便免疫化学测试 (FIT) 被评估为优先监视结肠镜检查.

研究的目的:

评估2样FIT在识别晚期瘤 (AN) 患者中的实用性.
确定FIT是否可以有效地对需要优先监视结肠镜的个体进行分拣.
为了优化内镜资源的分配.

主要方法:

在第三级护理环境中进行前性研究.
参与者在监测结肠镜检查后90天内完成了2个样本的FIT.
在中度和高风险个体中,FIT对AN的敏感性在各种便血红蛋白值 (2-80μg/g) 确定.

主要成果:

在766名患者中,8.6%有AN (包括5个CRC).
在中度风险个体中,FIT对AN的敏感度从73.5% (在2μg/g) 到10.2% (在80μg/g) 之间.
高风险个体的FIT敏感度相似,从70.6%到11.8%不等.
FIT血红蛋白结果≥10μg/g与AN检测独立相关 (OR,1.81).

结论:

在监视结肠镜检查之前使用FIT可为高级瘤 (AN) 提供有价值的风险评估.
这一策略使得患者的分组成为可能,提高了内镜资源管理的效率.
FIT可以帮助优先考虑个人进行及时监测结肠镜检查.

关键词:

结肠镜检查是一次结肠镜检查.结肠直肠新生病.便免疫化学试验便免疫化学试验监督监督监督监督监督监督

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