年龄,性别,肥胖和代谢综合征对左心室功能障碍的积极附加相互作用影响
Dan Zhou1,2, Zhongwen Ye3, Zhiqiang Nie1,4
1Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Journal of diabetes
|September 24, 2023
概括
代谢综合征 (MetS) 与心脏功能障碍有关,特别是左心室扩张性功能障碍 (LVDD) 和全球纵向应变 (GLS) 损伤. 在妇女,老年人和肥胖个体中预防MetS可以显著降低心血管风险.
科学领域:
- 心脏病学 心脏病学
- 代谢健康 代谢健康
- 心声回声扫描 (Echocardiography) 是一种心声回声扫描.
背景情况:
- 代谢综合征 (MetS) 是一个日益严重的公共卫生问题.
- 左心室扩张性功能障碍 (LVDD) 和收缩性功能障碍 (LVSD) 是心血管疾病的重要指标.
- 梅特斯和心脏功能障碍之间的相互作用需要进一步调查.
研究的目的:
- 调查代谢综合征 (MetS) 与左心室扩张性功能障碍 (LVDD) 和收缩性功能障碍 (LVSD) 之间的关联.
- 评估年龄,性别和肥胖与MetS对LVDD和LVSD的相互作用影响,定义为受损的全球纵向应变 (GLS).
主要方法:
- 预计从中国PEACE百万人项目招募5503名参与者.
- 所有参与者都进行了完整的心声回声检查.
- 多变量逻辑回归模型被用于分析加法和乘法相互作用.
主要成果:
- MetS与LVDD (OR 1.40) 和受损的GLS (OR 1.26) 独立相关.
- 在MetS和老年状况 (RERI 35.65),肥胖 (LVDD的RERI 2.14,GLS受损的RERI 3.37) 和性别 (女性LVDD的RERI 0.76) 之间观察到显著的附加相互作用.
- 甲状腺综合症的患病率为46.7%,LVDD为46.3%,GLS受损的患病率为12.5%.
结论:
- 代谢综合征是左心室扩张性功能障碍和全球纵向应变受损的独立危险因素.
- 专注于女性,老年人和肥胖个人的MetS预防的公共卫生策略可以大大降低心血管风险.
- 这些发现强调了管理METS的重要性,以防止高风险人群的心脏功能障碍.
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